Glandular epithelial AR inactivation enhances PTEN deletion-induced uterine pathology
نویسندگان
چکیده
منابع مشابه
Androgen actions via androgen receptor promote PTEN inactivation induced uterine cancer.
Haploinsufficient inactivating phosphatase and tensin homolog (Pten) mutations cause Cowden syndrome, an autosomal dominant risk genotype for hormone dependent reproductive cancers. As androgen actions mediated via the androgen receptor (AR) supports uterine growth and may modify uterine cancer risk, we hypothesized that a functional AR may increase PTEN inactivation induced uterine cancer. To ...
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ژورنال
عنوان ژورنال: Endocrine-Related Cancer
سال: 2016
ISSN: 1351-0088,1479-6821
DOI: 10.1530/erc-16-0039